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These are created by external sources or as a byproduct of normal cellular metabolism

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Common side effects include: Gastrointestinal symptoms (nausea, vomiting, diarrhea, constipation) Decreased appetite and potential malnutrition in vulnerable individuals Risk of hypoglycemia when combined with insulin or sulfonylureas Rare but serious risks including pancreatitis and gallbladder disease Important safety considerations include: Boxed warning for thyroid C-cell tumors in rodents

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1 This trial demonstrated clinically meaningful reductions in body weight after 68 weeks of treatment